AOC3 Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. Belongs to the copper/topaquinone oxidase family. Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Cell adhesion; EC; Membrane protein, integral; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component:  cell surface; cytoplasm; early endosome; endoplasmic reticulum; Golgi apparatus; integral component of membrane; microvillus; plasma membrane
Molecular Function:  aliphatic-amine oxidase activity; aminoacetone:oxygen oxidoreductase(deaminating) activity; calcium ion binding; copper ion binding; phenethylamine:oxygen oxidoreductase (deaminating) activity; primary amine oxidase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; quinone binding; tryptamine:oxygen oxidoreductase (deaminating) activity
Biological Process:  amine metabolic process; cell adhesion; inflammatory response; negative regulation of primary amine oxidase activity; oxidation-reduction process; response to antibiotic; xenobiotic metabolic process
Reference #:  Q16853 (UniProtKB)
Alt. Names/Synonyms: amine oxidase copper containing 3; amine oxidase, copper containing 3 (vascular adhesion protein 1); AOC3; Copper amine oxidase; HPAO; Membrane primary amine oxidase; placenta copper monamine oxidase; Semicarbazide-sensitive amine oxidase; SSAO; VAP-1; VAP1; Vascular adhesion protein 1
Gene Symbols: AOC3
Molecular weight: 84,622 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene