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OSTalpha
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Belongs to the OST-alpha family. Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 3q29 |
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Cellular Component:
basolateral plasma membrane; endoplasmic reticulum membrane; membrane; plasma membrane; protein-containing complex
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Molecular Function:
bile acid transmembrane transporter activity; protein binding; protein heterodimerization activity; protein homodimerization activity; transporter activity
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Biological Process:
bile acid and bile salt transport; bile acid secretion; transmembrane transport
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Disease: Cholestasis, Progressive Familial Intrahepatic, 6
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Reference #:
Q86UW1
(UniProtKB)
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Alt. Names/Synonyms: MGC39807; organic solute transporter alpha; Organic solute transporter subunit alpha; organic solute transporter, alpha subunit; OST-alpha; OSTA; OSTalpha; SLC51A; solute carrier family 51 alpha subunit; Solute carrier family 51 subunit alpha
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Gene Symbols: SLC51A
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Molecular weight:
37,735 Da
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Basal Isoelectric point:
8.89
Predict pI for various phosphorylation states
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