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IFIT1
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. Belongs to the IFIT family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of Human Ortholog: 10q23.31 |
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Cellular Component:
cytoplasm; cytosol; host cell
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Molecular Function:
protein binding; RNA binding
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Biological Process:
cellular response to exogenous dsRNA; cellular response to type I interferon; intracellular transport of viral protein in host cell; negative regulation of helicase activity; negative regulation of protein binding; negative regulation of viral genome replication; positive regulation of viral genome replication; regulation of defense response to virus; response to virus; type I interferon signaling pathway; viral process
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Reference #:
P09914
(UniProtKB)
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Alt. Names/Synonyms: C56; G10P1; GARG-16; IFI-56; IFI-56K; IFI56; IFIT-1; IFIT1; IFNAI1; interferon induced protein with tetratricopeptide repeats 1; Interferon, alpha-inducible protein (MW 56kD); Interferon-induced 56 kDa protein; interferon-induced protein 56; Interferon-induced protein with tetratricopeptide repeats 1; interferon-inducible mRNA 561; ISG56; P56; RNM561
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Gene Symbols: IFIT1
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Molecular weight:
55,360 Da
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Basal Isoelectric point:
6.75
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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