RFK Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. Detected in brain, placenta and urinary bladder. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - riboflavin; EC 2.7.1.26; Kinase, other
Chromosomal Location of human Ortholog: 9q21.13
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; metal ion binding; protein binding; riboflavin kinase activity
Biological Process:  apoptotic process; FMN biosynthetic process; phosphorylation; positive regulation of NAD(P)H oxidase activity; reactive oxygen species metabolic process; riboflavin biosynthetic process; riboflavin metabolic process
Reference #:  Q969G6 (UniProtKB)
Alt. Names/Synonyms: 0610038L10Rik; ATP:riboflavin 5'-phosphotransferase; Flavokinase; FLJ11149; RFK; Riboflavin kinase; RIFK
Gene Symbols: RFK
Molecular weight: 17,623 Da
Basal Isoelectric point: 7.85  Predict pI for various phosphorylation states
Select Structure to View Below

RFK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene