RFK Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. Detected in brain, placenta and urinary bladder. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - riboflavin; EC; Kinase, other
Chromosomal Location of human Ortholog: 9q21.13
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; metal ion binding; protein binding; riboflavin kinase activity
Biological Process:  apoptotic process; FMN biosynthetic process; phosphorylation; positive regulation of NAD(P)H oxidase activity; reactive oxygen species metabolic process; riboflavin biosynthetic process; riboflavin metabolic process
Reference #:  Q969G6 (UniProtKB)
Alt. Names/Synonyms: 0610038L10Rik; ATP:riboflavin 5'-phosphotransferase; Flavokinase; FLJ11149; RFK; Riboflavin kinase; RIFK
Gene Symbols: RFK
Molecular weight: 17,623 Da
Basal Isoelectric point: 7.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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