SPNS2 Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration. Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component:  integral component of membrane
Molecular Function:  sphingolipid transporter activity
Biological Process:  B cell homeostasis; bone development; lipid transport; lymph node development; lymphocyte migration; regulation of eye pigmentation; regulation of humoral immune response; sphingolipid metabolic process; sphingosine-1-phosphate receptor signaling pathway; T cell homeostasis; transmembrane transport
Disease: Deafness, Autosomal Recessive 115
Reference #:  Q8IVW8 (UniProtKB)
Alt. Names/Synonyms: DFNB115; Protein spinster homolog 2; SLC62A2; sphingolipid transporter 2; spinster homolog 2; spinster homolog 2 (Drosophila); SPNS sphingolipid transporter 2; SPNS2
Gene Symbols: SPNS2
Molecular weight: 58,044 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB