K19 Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Belongs to the intermediate filament family. Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of mouse Ortholog: 11 D|11 63.42 cM
Cellular Component:  apicolateral plasma membrane; cell periphery; costamere; dystrophin-associated glycoprotein complex; intermediate filament; plasma membrane; sarcolemma; terminal web; Z disc
Molecular Function:  protein binding; protein-containing complex binding; structural constituent of muscle; structural molecule activity
Biological Process:  cell differentiation involved in embryonic placenta development; Notch signaling pathway; sarcomere organization
Reference #:  P19001 (UniProtKB)
Alt. Names/Synonyms: AI663979; CK-19; cytokeratin 19; Cytokeratin-19; End; EndoC; K19; K1C19; keratin 19; keratin complex 1, acidic, gene 19; Keratin, type I cytoskeletal 19; Keratin-19; Krt-1.1; Krt-1.19; Krt1-1; Krt1-19; Krt19; MGC25344; OTTMUSP00000002396
Gene Symbols: Krt19
Molecular weight: 44,542 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene