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K19
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Belongs to the intermediate filament family. Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of human Ortholog: 17q21.2 |
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Cellular Component:
apicolateral plasma membrane; cell periphery; costamere; cytoskeleton; cytosol; intermediate filament; plasma membrane; sarcolemma; terminal web; Z disc
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Molecular Function:
protein binding; structural constituent of cytoskeleton; structural constituent of muscle
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Biological Process:
cell differentiation involved in embryonic placenta development; epithelial cell differentiation; intermediate filament organization; Notch signaling pathway; response to estrogen; sarcomere organization
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Reference #:
P08727
(UniProtKB)
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Alt. Names/Synonyms: 40-kDa keratin intermediate filament; CK-19; CK19; cytokeratin 19; Cytokeratin-19; K19; K1C19; K1CS; keratin 19; keratin 19, type I; Keratin, type I cytoskeletal 19; keratin, type I, 40-kd; Keratin-19; KRT19; MGC15366
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Gene Symbols: KRT19
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Molecular weight:
44,106 Da
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Basal Isoelectric point:
5.05
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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