RASA1 Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1. In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of rat Ortholog: 2q11
Cellular Component:  cytosol; membrane; nuclear membrane; plasma membrane; ruffle
Molecular Function:  GTPase activator activity; GTPase binding; kinase binding; phosphotyrosine residue binding; platelet-derived growth factor receptor binding; protein binding; protein kinase B binding; protein tyrosine kinase binding; protein-containing complex binding; receptor tyrosine kinase binding; signaling receptor binding; transmembrane transporter binding
Biological Process:  actin cytoskeleton organization; activation of GTPase activity; blood vessel morphogenesis; cell adhesion; cellular response to epidermal growth factor stimulus; cellular response to fibroblast growth factor stimulus; cellular response to platelet-derived growth factor stimulus; male genitalia development; mitotic cytokinesis; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of neuron apoptotic process; negative regulation of Ras protein signal transduction; positive regulation of fibroblast proliferation; positive regulation of glucose import; positive regulation of GTPase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein phosphorylation; regulation of actin filament polymerization; response to insulin; response to xenobiotic stimulus; signal transduction; vasculogenesis
Reference #:  P50904 (UniProtKB)
Alt. Names/Synonyms: GAP; GAPX; GTPase-activating protein; p120GAP; Ras GTPase-activating protein 1; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; RAS p21 protein activator 1; Rasa; Rasa1; RasGAP
Gene Symbols: Rasa1
Molecular weight: 115,440 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  T Cell Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene