GPR56
Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche. Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA. Plays an essential role in testis development. ADGRG1 N-terminal fragment: Plays a critical role in cancer progression by activating VEGFA production and angiogenesis through a signaling pathway mediated by PRKCA. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion; GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
Chromosomal Location of human Ortholog: 16q21 |
Cellular Component:
glial limiting end-foot; membrane; membrane raft; plasma membrane
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Molecular Function:
collagen binding; extracellular matrix binding; G protein-coupled receptor activity; heparin binding; protein binding
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; angiogenesis; brain development; cell adhesion; cell migration; cell surface receptor signaling pathway; cell-cell signaling; cerebral cortex radial glia-guided migration; cerebral cortex regionalization; G protein-coupled receptor signaling pathway; hematopoietic stem cell homeostasis; layer formation in cerebral cortex; negative regulation of cell population proliferation; negative regulation of neuron migration; neural precursor cell proliferation; positive regulation of cell adhesion; positive regulation of neural precursor cell proliferation; positive regulation of Rho protein signal transduction; protein kinase C signaling; Rho protein signal transduction; seminiferous tubule development; vascular endothelial growth factor production
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Disease: Polymicrogyria, Bilateral Frontoparietal; Polymicrogyria, Bilateral Perisylvian, Autosomal Recessive
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Reference #:
Q9Y653
(UniProtKB)
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Alt. Names/Synonyms: 7-transmembrane protein with no EGF-like N-terminal domains-1; ADGRG1; ADGRG1 C-terminal fragment; ADGRG1 CT; ADGRG1 N-terminal fragment; ADGRG1 NT; adhesion G protein-coupled receptor G1; Adhesion G-protein coupled receptor G1; AGRG1; BFPP; BPPR; DKFZp781L1398; EGF-TM7-like; G protein-coupled receptor 56; G-protein coupled receptor 56; GPR56; GPR56 7TM; GPR56 C-terminal fragment; GPR56 CT; GPR56 extracellular subunit; GPR56 N-terminal fragment; GPR56 NT; GPR56 seven-transmembrane subunit; GPR56 subunit alpha; GPR56 subunit beta; GPR56(C); GPR56(N); Protein TM7XN1; testicular tissue protein Li 77; TM7LN4; TM7XN1
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Gene Symbols: ADGRG1
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Molecular weight:
77,738 Da
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Basal Isoelectric point:
8.79
Predict pI for various phosphorylation states
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