CXCL17 Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions. 4-Cys CXCL17: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. Belongs to the intercrine alpha (chemokine CxC) family. Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component:  extracellular space
Molecular Function:  protein binding
Biological Process:  activation of MAPK activity; angiogenesis; cell differentiation; macrophage chemotaxis; negative regulation of inflammatory response; positive regulation of macrophage chemotaxis; positive regulation of monocyte chemotaxis; positive regulation of vascular endothelial growth factor production
Reference #:  Q6UXB2 (UniProtKB)
Alt. Names/Synonyms: 4-Cys CXCL17; 6-Cys CXCL17; C-X-C motif chemokine 17; C-X-C motif chemokine ligand 17; chemokine (C-X-C motif) ligand 17; CXCL17; CXL17; Dcip1; Dendritic cell and monocyte chemokine-like protein; DMC; MGC138300; UNQ473; VCC-1; VCC1; VEGF co-regulated chemokine 1; VEGF coregulated chemokine 1
Gene Symbols: CXCL17
Molecular weight: 13,819 Da
Basal Isoelectric point: 10.97  Predict pI for various phosphorylation states
Select Structure to View Below

CXCL17

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene