snRNP E Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. Belongs to the snRNP Sm proteins family. Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; Spliceosome
Chromosomal Location of human Ortholog: 1q32.1
Cellular Component:  catalytic step 2 spliceosome; cytosol; methylosome; nucleoplasm; nucleus; pICln-Sm protein complex; small nuclear ribonucleoprotein complex; SMN-Sm protein complex; spliceosomal complex; telomerase holoenzyme complex; U1 snRNP; U12-type spliceosomal complex; U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome; U4 snRNP; U4/U6 x U5 tri-snRNP complex; U7 snRNP
Molecular Function:  protein binding; RNA binding
Biological Process:  hair cycle; histone mRNA metabolic process; import into nucleus; mRNA splicing, via spliceosome; spliceosomal complex assembly; spliceosomal snRNP assembly; termination of RNA polymerase II transcription
Disease: Hypotrichosis 11
Reference #:  P62304 (UniProtKB)
Alt. Names/Synonyms: B-raf; HYPT11; RUXE; Sm protein E; Sm-E; Small nuclear ribonucleoprotein E; small nuclear ribonucleoprotein polypeptide E; SmE; snRNP E; snRNP-E; SNRPE
Gene Symbols: SNRPE
Molecular weight: 10,804 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene