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SPAG6
Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. Highly expressed in testis. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cancer Testis Antigen (CTA); Cell development/differentiation |
| Chromosomal Location of mouse Ortholog: 16|16 A3 |
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Cellular Component:
acrosomal vesicle; axonemal central apparatus; axoneme; cell projection; cilium; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; lateral wall of outer hair cell; manchette; microtubule; microtubule cytoskeleton; motile cilium; sperm principal piece
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Molecular Function:
microtubule binding; protein binding
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Biological Process:
cell division; cell projection organization; cerebrospinal fluid circulation; ear development; epithelial cilium movement involved in extracellular fluid movement; establishment of epithelial cell apical/basal polarity; establishment of localization in cell; fibroblast migration; filopodium assembly; flagellated sperm motility; motile cilium assembly; mucociliary clearance; neuron projection extension; non-motile cilium assembly; protein localization; regulation of cilium beat frequency; regulation of establishment of planar polarity; sperm axoneme assembly; spermatogenesis; stress fiber assembly; substrate-dependent cell migration, cell attachment to substrate; ventricular system development
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Reference #:
Q9JLI7
(UniProtKB)
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Alt. Names/Synonyms: Axoneme central apparatus protein; axoneme protein; PF1; Pf16; Protein PF16 homolog; SPAG6; Spag6; Spag6l; Spag6l1; sperm associated antigen 6-like; Sperm-associated antigen 6
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Gene Symbols: Spag6
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Molecular weight:
55,269 Da
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Basal Isoelectric point:
6.33
Predict pI for various phosphorylation states
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