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PPPM1A iso2
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. Belongs to the PP2C family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 14q23.1 |
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Cellular Component:
cytosol; membrane; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
calmodulin-dependent protein phosphatase activity; magnesium ion binding; manganese ion binding; myosin phosphatase activity; protein binding; protein serine/threonine phosphatase activity; R-SMAD binding
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Biological Process:
cellular response to transforming growth factor beta stimulus; dephosphorylation; N-terminal protein myristoylation; negative regulation of BMP signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of NIK/NF-kappaB signaling; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; peptidyl-threonine dephosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of DNA-templated transcription; positive regulation of protein export from nucleus; protein dephosphorylation; protein export from nucleus; regulation of cell cycle
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Reference #:
P35813-2
(UniProtKB)
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Alt. Names/Synonyms: FLJ42306; MGC9201; phosphatase 2C alpha; PP2C-alpha; PP2CA; PP2Calpha; PPM1A; PPPM1A; PPPM1A iso2; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 2C alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; protein phosphatase, Mg2+/Mn2+ dependent 1A; protein phosphatase, Mg2+/Mn2+ dependent, 1A
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Gene Symbols: PPM1A
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Molecular weight:
35,958 Da
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Basal Isoelectric point:
5.5
Predict pI for various phosphorylation states
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