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HDAC2
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. Belongs to the histone deacetylase family. HD type 1 subfamily. Widely expressed; lower levels in brain and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 10 19.44 cM|10 B1 |
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Cellular Component:
chromatin; chromosome, telomeric region; cytoplasm; ESC/E(Z) complex; heterochromatin; histone deacetylase complex; nucleoplasm; nucleus; NuRD complex; protein-containing complex; replication fork; RNA polymerase II transcription repressor complex; Sin3 complex; transcription regulator complex; transcription repressor complex
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Molecular Function:
chromatin binding; chromatin DNA binding; deacetylase activity; DNA-binding transcription factor binding; enzyme binding; heat shock protein binding; histone deacetylase activity; histone deacetylase binding; histone decrotonylase activity; histone H4K16 deacetylase activity; hydrolase activity; Krueppel-associated box domain binding; NF-kappaB binding; promoter-specific chromatin binding; protein binding; protein de-2-hydroxyisobutyrylase activity; protein lysine deacetylase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription corepressor binding
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Biological Process:
cardiac muscle cell development; cardiac muscle cell proliferation; cellular response to hydrogen peroxide; cellular response to trichostatin A; chromatin organization; chromatin remodeling; circadian regulation of gene expression; dendrite development; embryonic digit morphogenesis; epidermal cell differentiation; eyelid development in camera-type eye; fungiform papilla formation; hair follicle placode formation; heterochromatin organization; hippocampus development; histone deacetylation; histone H3 deacetylation; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle cell proliferation; negative regulation of cell migration; negative regulation of dendritic spine development; negative regulation of DNA binding; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of miRNA transcription; negative regulation of neuron projection development; negative regulation of peptidyl-lysine acetylation; negative regulation of stem cell population maintenance; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuron differentiation; odontogenesis of dentin-containing tooth; oligodendrocyte differentiation; positive regulation of cell population proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of interleukin-1 production; positive regulation of male mating behavior; positive regulation of oligodendrocyte differentiation; positive regulation of proteolysis; positive regulation of signaling receptor activity; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of STAT protein; protein deacetylation; regulation of cell fate specification; regulation of protein deacetylation; regulation of protein kinase B signaling; regulation of sarcomere organization; regulation of stem cell differentiation; rhythmic process
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Reference #:
P70288
(UniProtKB)
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Alt. Names/Synonyms: D10Wsu179; D10Wsu179e; HD2; HDAC 2; Hdac2; Histone deacetylase 2; mRPD3; OTTMUSP00000022803; YAF1; YY1 transcription factor-binding protein; Yy1b; Yy1bp
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Gene Symbols: Hdac2
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Molecular weight:
55,302 Da
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Basal Isoelectric point:
5.59
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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NF-kB Signaling
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Protein Acetylation
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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