SMAD9 transcription factor phosphorylated and activated by bone morphogenetic protein receptor kinases. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where they regulate transcription of target genes. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Two alternatively spliced products have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2q26
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; metal ion binding; protein binding
Biological Process:  BMP signaling pathway; bone development; cartilage development; cellular response to organic cyclic compound; hindbrain development; midbrain development; Mullerian duct regression; positive regulation of cell differentiation; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of transcription, DNA-templated; response to hypoxia; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development
Reference #:  O54835 (UniProtKB)
Alt. Names/Synonyms: MAD homolog 9; Madh8; Madh9; Mothers against decapentaplegic homolog 9; Mothers against DPP homolog 9; SMAD 9; SMAD family member 9; Smad8; Smad9
Gene Symbols: Smad9
Molecular weight: 48,992 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene