SMAD9 Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). Belongs to the dwarfin/SMAD family. Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 3|3 C
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; metal ion binding; protein binding
Biological Process:  BMP signaling pathway; bone development; cartilage development; cellular response to organic cyclic compound; hindbrain development; midbrain development; Mullerian duct regression; positive regulation of cell differentiation; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of transcription, DNA-templated; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development
Reference #:  Q9JIW5 (UniProtKB)
Alt. Names/Synonyms: MAD homolog 9; MAD homolog 9 (Drosophila); MADH6; Madh8; Madh9; Mothers against decapentaplegic homolog 9; Mothers against DPP homolog 9; OTTMUSP00000023428; SMAD 9; SMAD family member 9; Smad8; SMAD8A; SMAD8B; Smad9
Gene Symbols: Smad9
Molecular weight: 48,636 Da
Basal Isoelectric point: 8.48  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
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SMAD9

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene