HNF4 alpha Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes. Activates the transcription of CYP2C38. Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells. Belongs to the nuclear hormone receptor family. NR2 subfamily. 7 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of mouse Ortholog: 2 H3|2 84.32 cM
Cellular Component:  chromatin; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  arachidonic acid binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; fatty acid binding; fatty-acyl-CoA binding; long-chain fatty acyl-CoA binding; metal ion binding; nuclear receptor activity; palmitoyl-CoA hydrolase activity; protein binding; protein domain specific binding; protein homodimerization activity; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; signaling receptor binding; stearic acid binding; transcription cis-regulatory region binding; transcription coregulator binding; transcription corepressor binding; zinc ion binding
Biological Process:  acyl-CoA metabolic process; anatomical structure development; blood coagulation; cell differentiation; cell-cell junction organization; cholesterol homeostasis; establishment of tissue polarity; glucose homeostasis; hepatocyte differentiation; lipid homeostasis; lipid metabolic process; negative regulation of activation of Janus kinase activity; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of mitotic cell cycle; negative regulation of protein import into nucleus; negative regulation of tyrosine phosphorylation of STAT protein; ornithine metabolic process; phospholipid homeostasis; positive regulation of DNA-templated transcription; positive regulation of fatty acid biosynthetic process; positive regulation of gene expression; positive regulation of gluconeogenesis; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of gastrulation; regulation of insulin secretion; regulation of lipid metabolic process; regulation of microvillus assembly; regulation of transcription by RNA polymerase II; response to glucose; response to trichostatin A; rhythmic process; sex differentiation; signal transduction involved in regulation of gene expression; SMAD protein signal transduction; transcription by RNA polymerase II; triglyceride homeostasis; type B pancreatic cell development; xenobiotic metabolic process
Reference #:  P49698 (UniProtKB)
Alt. Names/Synonyms: hepatic nuclear factor 4, alpha; Hepatocyte nuclear factor 4-alpha; Hnf; HNF-; Hnf-4; HNF-4-alpha; Hnf4; HNF4 alpha; Hnf4a; Hnf4alpha; HNF4alpha10; HNF4alpha11; HNF4alpha12; MODY; MODY1; Nr2a1; Nuclear receptor 2A1; Nuclear receptor subfamily 2 group A member 1; TCF-14; Tcf14; Tcf4; Transcription factor 14; Transcription factor HNF-4
Gene Symbols: Hnf4a
Molecular weight: 52,684 Da
Basal Isoelectric point: 7.15  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  AMPK Signaling  |  Wnt/ß-Catenin Signaling
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HNF4 alpha

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA