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HNF4 alpha
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes. Activates the transcription of CYP2C38. Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells. Belongs to the nuclear hormone receptor family. NR2 subfamily. 7 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor; Transcription factor |
| Chromosomal Location of human Ortholog: 20q13.12 |
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Cellular Component:
chromatin; cytoplasm; nucleoplasm; nucleus
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Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; fatty acid binding; nuclear receptor activity; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding; signaling receptor binding; transcription cis-regulatory region binding; zinc ion binding
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Biological Process:
anatomical structure development; blood coagulation; cell differentiation; cholesterol homeostasis; glucose homeostasis; intracellular receptor signaling pathway; lipid homeostasis; lipid metabolic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; ornithine metabolic process; phospholipid homeostasis; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of gastrulation; regulation of insulin secretion; regulation of lipid metabolic process; regulation of transcription by RNA polymerase II; response to glucose; rhythmic process; sex differentiation; signal transduction involved in regulation of gene expression; SMAD protein signal transduction; transcription by RNA polymerase II; triglyceride homeostasis; xenobiotic metabolic process
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Disease: Diabetes Mellitus, Noninsulin-dependent; Fanconi Renotubular Syndrome 4 With Maturity-onset Diabetes Of The Young; Maturity-onset Diabetes Of The Young, Type 1
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Reference #:
P41235
(UniProtKB)
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Alt. Names/Synonyms: FLJ39654; FRTS4; hepatic nuclear factor 4 alpha; hepatocyte nuclear factor 4 alpha; hepatocyte nuclear factor 4, alpha; Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; HNF4; HNF4 alpha; HNF4A; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; HNF4alpha10/11/12; MODY; MODY1; NR2A1; NR2A21; Nuclear receptor subfamily 2 group A member 1; TCF; TCF-14; TCF14; Transcription factor 14; Transcription factor HNF-4; transcription factor-14
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Gene Symbols: HNF4A
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Molecular weight:
52,785 Da
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Basal Isoelectric point:
7.15
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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AMPK Signaling
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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