RNF7 Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. Belongs to the RING-box family. Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 9|9 E3.3
Cellular Component:  Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; Cul4-RING E3 ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; Cul7-RING ubiquitin ligase complex; cullin-RING ubiquitin ligase complex; cytoplasm; cytosol; nuclear SCF ubiquitin ligase complex; nucleoplasm; nucleus
Molecular Function:  cullin family protein binding; metal ion binding; NEDD8 transferase activity; protein binding; ubiquitin protein ligase activity; zinc ion binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic mitochondrial changes; cerebral cortex radially oriented cell migration; intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of apoptotic process; protein neddylation; radial glia guided migration of Purkinje cell; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process
Reference #:  Q9WTZ1 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000026453; Rbx2; RING finger protein 7; RING-box protein 2; Rnf7; Sag; Sensitive to apoptosis gene protein
Gene Symbols: Rnf7
Molecular weight: 12,707 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene