SIAT1 Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. Belongs to the glycosyltransferase 29 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 11q23
Cellular Component:  endoplasmic reticulum; extracellular region; Golgi apparatus; Golgi cisterna membrane; Golgi medial cisterna; Golgi membrane; Golgi trans cisterna; integral component of membrane
Molecular Function:  beta-galactoside alpha-2,6-sialyltransferase activity; protein homodimerization activity; sialyltransferase activity
Biological Process:  N-acetylneuraminate metabolic process; negative regulation of chemotaxis; negative regulation of macrophage apoptotic process; positive regulation of mononuclear cell proliferation; protein glycosylation; protein N-linked glycosylation via asparagine; protein sialylation; regulation of substrate adhesion-dependent cell spreading; response to ethanol; sialylation
Reference #:  P13721 (UniProtKB)
Alt. Names/Synonyms: Alpha 2,6-ST 1; beta galactoside alpha 2,6 sialyltransferase 1; Beta-galactoside alpha-2,6-sialyltransferase 1; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; Sialyltransferase 1; Sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); Sialyltransferase 1 (beta-galactoside alpha-26-sialytransferase); Siat1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1; ST6Gal I; St6gal1; ST6GalI
Gene Symbols: St6gal1
Molecular weight: 46,732 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene