SIAT1 a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. Is normally found in the trans cisternae of the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.99.1; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 16 B1|16 14.03 cM
Cellular Component:  endoplasmic reticulum; extracellular region; Golgi apparatus; Golgi medial cisterna; Golgi trans cisterna; integral component of membrane; membrane
Molecular Function:  beta-galactoside alpha-2,6-sialyltransferase activity; sialyltransferase activity; transferase activity; transferase activity, transferring glycosyl groups
Biological Process:  N-acetylneuraminate metabolic process; negative regulation of chemotaxis; negative regulation of macrophage apoptotic process; positive regulation of mononuclear cell proliferation; protein glycosylation; protein N-linked glycosylation via asparagine; regulation of substrate adhesion-dependent cell spreading
Reference #:  Q64685 (UniProtKB)
Alt. Names/Synonyms: Alpha 2,6-ST 1; AW742324; beta galactoside alpha 2,6 sialyltransferase 1; Beta-galactoside alpha-2,6-sialyltransferase 1; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; MGC116663; OTTMUSP00000031674; OTTMUSP00000032134; Sialyltransferase 1; Siat1; St6gal; ST6Gal I; St6gal1; ST6GalI
Gene Symbols: St6gal1
Molecular weight: 46,586 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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SIAT1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene