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LOXL3
Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin. Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated. Also able to catalyze deacetylation of lysine residues on STAT3. Isoform 1: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII. Isoform 2: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV. Belongs to the lysyl oxidase family. Isoform 1: Predominantly detected in the heart, placenta, lung, and small intestine (PubMed:17018530). Isoform 2: Highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung (PubMed:17018530). In eye, present in all layers of corneas as well as in the limbus and conjunctiva (at protein level) (PubMed:26218558). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.4.3.-; Oxidoreductase; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 2p13.1 |
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Cellular Component:
collagen-containing extracellular matrix; cytoplasm; extracellular region; extracellular space; membrane; nucleus
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Molecular Function:
copper ion binding; fibronectin binding; protein binding; protein-lysine 6-oxidase activity; scavenger receptor activity
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Biological Process:
collagen fibril organization; endocytosis; epithelial to mesenchymal transition; fibronectin fibril organization; inflammatory response; lung development; negative regulation of DNA-templated transcription; negative regulation of T-helper 17 cell lineage commitment; peptidyl-lysine oxidation; positive regulation of integrin-mediated signaling pathway; roof of mouth development; somite development; spinal cord development
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Disease: Myopia 28, Autosomal Recessive
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Reference #:
P58215
(UniProtKB)
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Alt. Names/Synonyms: LOXL; LOXL3; Lysyl oxidase homolog 3; lysyl oxidase like 3; lysyl oxidase-like 3; Lysyl oxidase-like protein 3
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Gene Symbols: LOXL3
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Molecular weight:
83,166 Da
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Basal Isoelectric point:
6.4
Predict pI for various phosphorylation states
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