AQP4 Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability. Belongs to the MIP/aquaporin (TC 1.A.8) family. Detected in skeletal muscle (PubMed:29055082). Detected in stomach, along the glandular base region of the fundic gland (at protein level) (PubMed:8601457). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary (PubMed:7559426, PubMed:8601457). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 18p13
Cellular Component:  astrocyte end-foot; basal plasma membrane; basolateral plasma membrane; cell projection membrane; cell-cell junction; cytoplasm; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; pore complex; protein-containing complex; sarcolemma; T-tubule
Molecular Function:  channel activity; identical protein binding; porin activity; protein binding; water channel activity
Biological Process:  carbon dioxide transport; cell-cell adhesion; cellular response to estradiol stimulus; cellular response to glucose stimulus; cellular response to interferon-gamma; cellular response to interleukin-1; cellular response to interleukin-6; cellular water homeostasis; cerebrospinal fluid circulation; female pregnancy; hyperosmotic salinity response; multicellular organismal water homeostasis; negative regulation of cell adhesion molecule production; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; protein homooligomerization; protein homotetramerization; regulation of vascular endothelial growth factor production; renal water absorption; response to glucocorticoid; response to radiation; sensory perception of sound; transmembrane transport; water homeostasis; water transport
Reference #:  P47863 (UniProtKB)
Alt. Names/Synonyms: AQP-4; Aqp4; AQP4.M23; aquaporin 4; aquaporin 4.M23; Aquaporin-4; Mercurial-insensitive water channel; MIWC; MIWC2; WCH4
Gene Symbols: Aqp4
Molecular weight: 34,480 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene