AQP4 a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 18 A1|18 8.74 cM
Cellular Component:  astrocyte end-foot; basal plasma membrane; basolateral plasma membrane; cell projection membrane; cell-cell junction; cytoplasm; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; protein-containing complex; sarcolemma; T-tubule
Molecular Function:  channel activity; identical protein binding; porin activity; protein binding; water channel activity
Biological Process:  carbon dioxide transport; cellular response to glucose stimulus; cellular response to interferon-gamma; cellular water homeostasis; cerebrospinal fluid circulation; negative regulation of cell adhesion molecule production; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; protein homooligomerization; protein homotetramerization; regulation of vascular endothelial growth factor production; renal water absorption; sensory perception of sound; water homeostasis; water transport
Reference #:  P55088 (UniProtKB)
Alt. Names/Synonyms: AQP-4; Aqp4; aquaporin 4; Aquaporin-4; Mercurial-insensitive water channel; MIWC; WCH4
Gene Symbols: Aqp4
Molecular weight: 34,436 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene