AQP4 Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability. Belongs to the MIP/aquaporin (TC 1.A.8) family. Detected in skeletal muscle (PubMed:29055082). Detected in stomach, along the glandular base region of the fundic gland (at protein level) (PubMed:8601457). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary (PubMed:7559426, PubMed:8601457). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component:  astrocyte end-foot; basolateral plasma membrane; cytoplasm; external side of plasma membrane; integral component of plasma membrane; plasma membrane; sarcolemma
Molecular Function:  protein binding; water channel activity
Biological Process:  cellular response to interferon-gamma; cellular water homeostasis; cerebrospinal fluid circulation; multicellular organismal water homeostasis; protein homotetramerization; renal water homeostasis; transmembrane transport; water homeostasis; water transport
Reference #:  P55087 (UniProtKB)
Alt. Names/Synonyms: AQP-4; AQP4; aquaporin 4; aquaporin type4; Aquaporin-4; HMIWC2; Mercurial-insensitive water channel; MGC22454; MIWC; WCH4
Gene Symbols: AQP4
Molecular weight: 34,830 Da
Basal Isoelectric point: 7.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein