SF1 a splicing factor necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. Phosphorylation of SF1 by cGMP-dependent protein kinase regulates spliceosome assembly. Binds U2AF2. Interacts with U1 snRNA. Binds EWSR1, FUS and TAF15. Six alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  nuclear body; nucleoplasm; nucleus; ribosome; spliceosomal complex
Molecular Function:  identical protein binding; pre-mRNA branch point binding; protein binding; RNA binding; transcription corepressor activity; zinc ion binding
Biological Process:  Leydig cell differentiation; male sex determination; mRNA 3'-splice site recognition; mRNA splicing, via spliceosome; negative regulation of nucleic acid-templated transcription; negative regulation of smooth muscle cell proliferation; nuclear body organization; regulation of steroid biosynthetic process; spliceosomal complex assembly
Reference #:  Q15637 (UniProtKB)
Alt. Names/Synonyms: BBP; D11S636; Mammalian branch point-binding protein; mBBP; SF01; SF1; Splicing factor 1; Transcription factor ZFM1; ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162; ZNF162
Gene Symbols: SF1
Molecular weight: 68,330 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Select Structure to View Below

SF1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein