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SF1
a splicing factor necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. Phosphorylation of SF1 by cGMP-dependent protein kinase regulates spliceosome assembly. Binds U2AF2. Interacts with U1 snRNA. Binds EWSR1, FUS and TAF15. Six alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor |
| Chromosomal Location of Human Ortholog: 11q13.1 |
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Cellular Component:
nuclear body; nucleoplasm; nucleus; ribosome; spliceosomal complex
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Molecular Function:
identical protein binding; pre-mRNA branch point binding; protein binding; RNA binding; transcription corepressor activity; zinc ion binding
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Biological Process:
Leydig cell differentiation; male sex determination; mRNA 3'-splice site recognition; mRNA splicing, via spliceosome; negative regulation of nucleic acid-templated transcription; negative regulation of smooth muscle cell proliferation; nuclear body organization; regulation of steroid biosynthetic process; spliceosomal complex assembly
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Reference #:
Q15637
(UniProtKB)
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Alt. Names/Synonyms: BBP; D11S636; Mammalian branch point-binding protein; mBBP; SF01; SF1; Splicing factor 1; Transcription factor ZFM1; ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162; ZNF162
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Gene Symbols: SF1
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Molecular weight:
68,330 Da
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Basal Isoelectric point:
9.07
Predict pI for various phosphorylation states
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