DYN1 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle
Chromosomal Location of Human Ortholog: 3p12
Cellular Component:  axon; cytoplasm; cytoplasmic vesicle; dendritic spine; dendritic spine head; glutamatergic synapse; Golgi apparatus; membrane; membrane coat; microtubule; nucleoplasm; nucleus; photoreceptor inner segment; photoreceptor ribbon synapse; plasma membrane; postsynaptic density; postsynaptic endocytic zone membrane; postsynaptic membrane; presynaptic endocytic zone membrane; protein-containing complex; synapse; synaptic vesicle; varicosity
Molecular Function:  D2 dopamine receptor binding; GTP binding; GTPase activity; identical protein binding; microtubule binding; nitric-oxide synthase binding; protein binding; protein C-terminus binding; protein dimerization activity; protein kinase binding; protein-containing complex binding; SH3 domain binding
Biological Process:  adult locomotory behavior; clathrin-dependent endocytosis; endocytosis; endosome organization; G protein-coupled receptor internalization; modulation of chemical synaptic transmission; positive regulation of synaptic vesicle endocytosis; positive regulation of synaptic vesicle recycling; postsynaptic neurotransmitter receptor internalization; protein tetramerization; receptor internalization; receptor-mediated endocytosis; regulation of synapse structure or activity; regulation of synaptic vesicle endocytosis; response to amyloid-beta; sensory perception of sound; synaptic transmission, GABAergic; synaptic vesicle budding from presynaptic endocytic zone membrane; synaptic vesicle endocytosis; toxin transport
Reference #:  P21575 (UniProtKB)
Alt. Names/Synonyms: B-dynamin; D100; Dnm; Dnm1; DYN1; dynamin 1; Dynamin, brain; Dynamin-1
Gene Symbols: Dnm1
Molecular weight: 97,295 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene