DYN1 a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle
Chromosomal Location of Human Ortholog: 3p12
Cellular Component:  axon; cytoplasm; cytoplasmic vesicle; dendritic spine; dendritic spine head; glutamatergic synapse; Golgi apparatus; membrane; membrane coat; microtubule; nucleoplasm; nucleus; photoreceptor inner segment; photoreceptor ribbon synapse; plasma membrane; postsynaptic density; postsynaptic endocytic zone membrane; postsynaptic membrane; presynaptic endocytic zone membrane; protein-containing complex; synapse; synaptic vesicle; varicosity
Molecular Function:  D2 dopamine receptor binding; GTP binding; GTPase activity; identical protein binding; microtubule binding; nitric-oxide synthase binding; protein binding; protein C-terminus binding; protein dimerization activity; protein kinase binding; protein-containing complex binding; SH3 domain binding
Biological Process:  adult locomotory behavior; clathrin-dependent endocytosis; endocytosis; endosome organization; G protein-coupled receptor internalization; modulation of chemical synaptic transmission; positive regulation of synaptic vesicle endocytosis; positive regulation of synaptic vesicle recycling; postsynaptic neurotransmitter receptor internalization; protein tetramerization; receptor internalization; receptor-mediated endocytosis; regulation of synapse structure or activity; regulation of synaptic vesicle endocytosis; response to amyloid-beta; sensory perception of sound; synaptic transmission, GABAergic; synaptic vesicle budding from presynaptic endocytic zone membrane; synaptic vesicle endocytosis; toxin transport
Reference #:  P21575 (UniProtKB)
Alt. Names/Synonyms: B-dynamin; D100; Dnm; Dnm1; DYN1; dynamin 1; Dynamin, brain; Dynamin-1
Gene Symbols: Dnm1
Molecular weight: 97,295 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DYN1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene