INPP5E Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Can convert lipid substrates, but also water soluble inositol phosphates.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 3p13
Cellular Component:  axoneme; cilium; cytoplasm; Golgi cisterna membrane; Golgi membrane; plasma membrane; ruffle
Molecular Function:  hydrolase activity; inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-4,5-bisphosphate phosphatase activity
Biological Process:  inositol phosphate dephosphorylation; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein localization to cilium; negative regulation of translation; phosphatidylinositol dephosphorylation; phosphatidylinositol metabolic process
Reference #:  Q9WVR1 (UniProtKB)
Alt. Names/Synonyms: 72 kDa inositol polyphosphate 5-phosphatase; inositol polyphosphate-5-phosphatase E; Inpp5e; RGD620478
Gene Symbols: Inpp5e
Molecular weight: 72,238 Da
Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states
Select Structure to View Below

INPP5E

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  ENZYME  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein