ADAM10 Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling (By similarity).
Protein type: Cell adhesion; Cell surface; EC; Membrane protein, integral; Motility/polarity/chemotaxis; Protease; Vesicle
Chromosomal Location of Human Ortholog: 8q24
Cellular Component:  cell surface; cytoplasm; dendrite; dendritic spine; glutamatergic synapse; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; integral component of membrane; membrane; neuronal cell body; nucleus; perinuclear endoplasmic reticulum; postsynapse; postsynaptic density; postsynaptic membrane; synaptic vesicle; tetraspanin-enriched microdomain; trans-Golgi network
Molecular Function:  endopeptidase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; protein homodimerization activity; protein kinase binding; SH3 domain binding
Biological Process:  amyloid-beta formation; constitutive protein ectodomain proteolysis; in utero embryonic development; membrane protein ectodomain proteolysis; monocyte activation; negative regulation of cell adhesion; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of apoptotic process; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of T cell chemotaxis; postsynapse organization; protein phosphorylation; protein processing; regulation of dendritic spine morphogenesis; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of osteoclast differentiation; response to antineoplastic agent; response to tumor necrosis factor; spermatogenesis
Reference #:  Q10743 (UniProtKB)
Alt. Names/Synonyms: ADAM metallopeptidase domain 10; Adam10; Disintegrin and metalloproteinase domain-containing protein 10; Madm; RGD2032
Gene Symbols: Adam10
Molecular weight: 60,445 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Notch Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  ENZYME  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene