|
H2B
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2B family. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding |
| Chromosomal Location of cow Ortholog: (6p21.3) |
|
Cellular Component:
nucleosome
|
|
Molecular Function:
DNA binding; protein heterodimerization activity; structural constituent of chromatin
|
|
Reference #:
NP_001032546
(RefSeq)
|
|
Alt. Names/Synonyms: H2B; H2B clustered histone 19; histone H2B type 1; histone H2B-like
|
|
Gene Symbols: H2BC19
|
|
Molecular weight:
13,775 Da
|
|
Basal Isoelectric point:
10.32
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
