H2B Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2B family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 13|13 A3.1
Cellular Component:  cytosol; nucleoplasm; nucleus
Reference #:  P10853 (UniProtKB)
Alt. Names/Synonyms: H2B 291A; H2b-f; H2b-j; H2b-l; H2b-n; H2B1F; Hist1h2bf; Hist1h2bj; Hist1h2bl; Hist1h2bn; histone 1, H2bf; histone cluster 1, H2bf; Histone H2B type 1-F/J/L; OTTMUSP00000000526
Gene Symbols: Hist1h2bn
Molecular weight: 13,805 Da
Basal Isoelectric point: 10.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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H2B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein