PFKP
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade E sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other |
Chromosomal Location of rat Ortholog: 17q12.2 |
Cellular Component:
6-phosphofructokinase complex; cytoplasm; cytosol; membrane
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Molecular Function:
6-phosphofructokinase activity; AMP binding; ATP binding; fructose-6-phosphate binding; identical protein binding; metal ion binding; monosaccharide binding; protein-containing complex binding
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Biological Process:
canonical glycolysis; cellular response to leukemia inhibitory factor; fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; glycolytic process; glycolytic process through fructose-6-phosphate; phosphorylation
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Reference #:
P47860
(UniProtKB)
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Alt. Names/Synonyms: 6-phosphofructo-1-kinase, C-type; 6-phosphofructokinase type C; ATP-dependent 6-phosphofructokinase, platelet type; K6PP; MGC105718; PFK-C; Pfkc; Pfkp; Phosphofructo-1-kinase isozyme C; Phosphofructokinase 1; phosphofructokinase, platelet; Phosphohexokinase
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Gene Symbols: Pfkp
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Molecular weight:
85,720 Da
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Basal Isoelectric point:
6.94
Predict pI for various phosphorylation states
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CST Pathways:
Warburg Effect
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