PFKP phosphofructokinase, platelet type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC; Kinase, other
Chromosomal Location of Human Ortholog: 17q12.2
Cellular Component:  6-phosphofructokinase complex; cytoplasm; cytosol; membrane
Molecular Function:  6-phosphofructokinase activity; AMP binding; ATP binding; fructose-6-phosphate binding; identical protein binding; metal ion binding; monosaccharide binding; protein-containing complex binding
Biological Process:  canonical glycolysis; cellular response to leukemia inhibitory factor; fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; glucose catabolic process; glycolytic process; glycolytic process through fructose-6-phosphate; protein homotetramerization
Reference #:  P47860 (UniProtKB)
Alt. Names/Synonyms: 6-phosphofructo-1-kinase, C-type; 6-phosphofructokinase type C; ATP-dependent 6-phosphofructokinase, platelet type; K6PP; MGC105718; PFK-C; Pfkc; Pfkp; Phosphofructo-1-kinase isozyme C; Phosphofructokinase 1; phosphofructokinase, platelet; Phosphohexokinase
Gene Symbols: Pfkp
Molecular weight: 85,720 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene