|
RCC1
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell cycle regulation; GEF; GEF, Ras |
| Chromosomal Location of rat Ortholog: 5q36 |
|
Cellular Component:
chromatin; condensed nuclear chromosome; cytoplasm; nucleoplasm; nucleus; protein-containing complex
|
|
Molecular Function:
chromatin binding; guanyl-nucleotide exchange factor activity; histone binding; nucleosomal DNA binding; nucleosome binding; protein heterodimerization activity; small GTPase binding; sulfate binding
|
|
Biological Process:
chromosome segregation; G1/S transition of mitotic cell cycle; mitotic spindle organization; regulation of mitotic nuclear division; spindle assembly
|
|
Reference #:
B1H227
(UniProtKB)
|
|
Alt. Names/Synonyms: LOC682908; LOC682908 protein; Rcc1; regulator of chromosome condensation 1; RGD1592835
|
|
Gene Symbols: Rcc1
|
|
Molecular weight:
45,111 Da
|
|
Basal Isoelectric point:
8.06
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
