DFFA Inhibitor of the caspase-activated DNase (DFF40). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Chromosomal Location of Human Ortholog: 5q36
Cellular Component:  cytosol; lipid droplet; nuclear chromatin; nucleus; plasma membrane
Molecular Function:  deoxyribonuclease inhibitor activity; protein binding involved in protein folding; protein domain specific binding
Biological Process:  apoptotic DNA fragmentation; chaperone-mediated protein folding; negative regulation of apoptotic DNA fragmentation; negative regulation of deoxyribonuclease activity; negative regulation of execution phase of apoptosis; positive regulation of apoptotic process; thymocyte apoptotic process
Reference #:  Q498U6 (UniProtKB)
Alt. Names/Synonyms: Dffa; DNA fragmentation factor subunit alpha; DNA fragmentation factor, alpha; RGD620334
Gene Symbols: Dffa
Molecular weight: 28,759 Da
Basal Isoelectric point: 4.35  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein