DNAM-1 Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding. Expressed by peripheral blood T-lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral
Cellular Component: 
Reference #:  D3ZS97 (UniProtKB)
Alt. Names/Synonyms: Cd226; CD226 antigen (Predicted), isoform CRA_b; DNAM-1; RGD1311513
Gene Symbols: Cd226
Molecular weight: 39,607 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
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DNAM-1

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  GeneCards  |  UniProtKB  |  GenPept  |  Ensembl Gene  |  Ensembl Protein