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AVIL
Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. Belongs to the villin/gelsolin family. Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 7q22 |
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Cellular Component:
actin cytoskeleton; actin filament; axon; cell projection; cytoplasm; focal adhesion; lamellipodium; neuron projection
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Molecular Function:
actin binding; actin filament binding; Arp2/3 complex binding; phosphatidylinositol-4,5-bisphosphate binding
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Biological Process:
actin filament organization; actin filament severing; actin polymerization or depolymerization; barbed-end actin filament capping; cilium assembly; nervous system development; positive regulation of lamellipodium assembly; positive regulation of neuron projection development; regulation of diacylglycerol biosynthetic process
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Reference #:
Q9WU06
(UniProtKB)
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Alt. Names/Synonyms: Advil; Advillin; Avil; Peripheral nervous system villin-like protein; Pervin; rCG_59474; RGD620301
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Gene Symbols: Avil
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Molecular weight:
91,894 Da
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Basal Isoelectric point:
5.18
Predict pI for various phosphorylation states
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