PHKA1 Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. Belongs to the phosphorylase b kinase regulatory chain family. Muscle specific. Isoform 1 is predominant in vastus lateralis muscle. Isoform 2 predominates slightly in heart, and it predominates clearly in the other tissues tested. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: Xq22
Cellular Component:  phosphorylase kinase complex; plasma membrane
Molecular Function:  calmodulin binding; catalytic activity; choline-phosphate cytidylyltransferase activity
Biological Process:  CDP-choline pathway; glycogen metabolic process; phosphatidylcholine biosynthetic process; protein autophosphorylation
Reference #:  Q64649 (UniProtKB)
Alt. Names/Synonyms: KPB1; Pcyt1b; PhK-alpha-subunit; Phka1; phosphorylase B kinase alpha subunit; Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase kinase alpha M subunit; phosphorylase kinase alpha-subunit; phosphorylase kinase, alpha 1
Gene Symbols: Phka1
Molecular weight: 139,155 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
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PHKA1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene