ZP1 The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida. Belongs to the ZP domain family. ZPB subfamily. Oocytes. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component:  collagen-containing extracellular matrix; extracellular region; integral component of membrane; plasma membrane
Molecular Function:  protein binding
Biological Process:  binding of sperm to zona pellucida
Disease: Oocyte Maturation Defect
Reference #:  P60852 (UniProtKB)
Alt. Names/Synonyms: MGC87693; Processed zona pellucida sperm-binding protein 1; Zona pellucida glycoprotein 1; zona pellucida glycoprotein 1 (sperm receptor); zona pellucida protein 1; Zona pellucida sperm-binding protein 1; Zp-1; ZP1
Gene Symbols: ZP1
Molecular weight: 70,049 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene