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TAF4B
Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Belongs to the TAF4 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Chromosomal Location of Human Ortholog: 18q11.2 |
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Cellular Component:
cytoplasm; fibrillar center; nucleoplasm
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; NF-kappaB binding; protein heterodimerization activity
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Biological Process:
oogenesis; regulation of signal transduction by p53 class mediator; spermatogenesis; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter
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Disease: Spermatogenic Failure 13
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Reference #:
Q92750
(UniProtKB)
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Alt. Names/Synonyms: TAF(II)105; TAF2C2; TAF4B; TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa; TAFII-105; TAFII105; TATA box binding protein (TBP)-associated factor 4B; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD; transcription initiation factor TFIID 105 kD subunit; Transcription initiation factor TFIID 105 kDa subunit; Transcription initiation factor TFIID subunit 4B
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Gene Symbols: TAF4B
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Molecular weight:
91,091 Da
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Basal Isoelectric point:
9.59
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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