TAF4B Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Belongs to the TAF4 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component:  cytoplasm; fibrillar center; nucleoplasm
Molecular Function:  DNA binding; DNA-binding transcription factor activity; NF-kappaB binding; protein heterodimerization activity
Biological Process:  oogenesis; regulation of signal transduction by p53 class mediator; spermatogenesis; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter
Disease: Spermatogenic Failure 13
Reference #:  Q92750 (UniProtKB)
Alt. Names/Synonyms: TAF(II)105; TAF2C2; TAF4B; TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa; TAFII-105; TAFII105; TATA box binding protein (TBP)-associated factor 4B; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD; transcription initiation factor TFIID 105 kD subunit; Transcription initiation factor TFIID 105 kDa subunit; Transcription initiation factor TFIID subunit 4B
Gene Symbols: TAF4B
Molecular weight: 91,091 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB