MRLC2 Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. Ubiquitously expressed in various hematopoietic cells. Note: This description may include information from UniProtKB.
Protein type: Contractile
Cellular Component:  actomyosin; myosin II complex; myosin II filament
Molecular Function:  ATPase activity; calcium ion binding
Biological Process:  actomyosin structure organization
Reference #:  Q5E9E2 (UniProtKB)
Alt. Names/Synonyms: fast skeletal myosin light chain 2; MRCL3; MYL12A; MYL9; myosin regulatory light chain; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain 2-A, smooth muscle isoform; Myosin regulatory light polypeptide 9; myosin, light chain 12A, regulatory, non-sarcomeric; MYRL2
Gene Symbols: MYL12A
Molecular weight: 19,865 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  TGF-ß Signaling
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MRLC2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein