EPOR Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. Belongs to the type I cytokine receptor family. Type 1 subfamily. Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of rat Ortholog: 8q13
Cellular Component:  cytoplasm; external side of plasma membrane; integral component of membrane
Molecular Function:  erythropoietin receptor activity; identical protein binding
Biological Process:  aging; brain development; cellular response to kainic acid; decidualization; erythropoietin-mediated signaling pathway; heart development; negative regulation of hydrogen peroxide-induced cell death; negative regulation of neuron apoptotic process; negative regulation of nitric oxide biosynthetic process; positive regulation of cell proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; response to hypoxia; signal transduction
Reference #:  Q07303 (UniProtKB)
Alt. Names/Synonyms: EPO-R; Epor; Erythropoietin receptor; MGC108723
Gene Symbols: Epor
Molecular weight: 55,500 Da
Basal Isoelectric point: 5.07  Predict pI for various phosphorylation states
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EPOR

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene