EPOR erythropoietin receptor: a member of the cytokine receptor family. Mediates erythropoietin-induced erythroblast proliferation, differentiation and survival. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. Forms homodimers on EPO stimulation. Tyrosine-phosphorylated EpoR may bind several SH2 domain-containing proteins including LYN, the adapter protein APS, SHP-1, SHP-2, JAK2, PI3 kinases, STAT5A/B, SOCS3, and CRKL. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Three alternatively-spliced isoforms have been described. Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 9 A3|9 7.93 cM
Cellular Component:  cytoplasm; external side of plasma membrane; extracellular region; integral component of membrane; membrane; plasma membrane
Molecular Function:  cytokine receptor activity; erythropoietin receptor activity; identical protein binding; protein binding; transmembrane signaling receptor activity
Biological Process:  brain development; cardiac muscle tissue morphogenesis; decidualization; heart development; heart morphogenesis; negative regulation of hydrogen peroxide-induced cell death; negative regulation of neuron apoptotic process; negative regulation of nitric oxide biosynthetic process; positive regulation of cell proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; signal transduction; vasculogenesis involved in coronary vascular morphogenesis; ventricular cardiac muscle tissue morphogenesis; viral process; visceral serous pericardium development
Reference #:  P14753 (UniProtKB)
Alt. Names/Synonyms: EPO-R; Epor; Erythropoietin receptor
Gene Symbols: Epor
Molecular weight: 55,194 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
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EPOR

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene