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EPOR
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. Belongs to the type I cytokine receptor family. Type 1 subfamily. Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, cytokine |
| Chromosomal Location of human Ortholog: 19p13.2 |
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Cellular Component:
external side of plasma membrane; extracellular region; nuclear speck; plasma membrane
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Molecular Function:
erythropoietin receptor activity; identical protein binding; protein binding
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Biological Process:
brain development; cytokine-mediated signaling pathway; decidualization; erythropoietin-mediated signaling pathway; heart development; hemopoiesis; positive regulation of cell population proliferation; signal transduction
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Disease: Erythrocytosis, Familial, 1
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Reference #:
P19235
(UniProtKB)
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Alt. Names/Synonyms: EPO-R; EPOR; Erythropoietin receptor; MGC138358; truncated erythropoietin receptor
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Gene Symbols: EPOR
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Molecular weight:
55,065 Da
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Basal Isoelectric point:
4.64
Predict pI for various phosphorylation states
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