PIK3CG Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. Belongs to the PI3/PI4-kinase family. Pancreas, skeletal muscle, liver and heart. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; EC 2.7.11.1; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12|12 A3
Cellular Component:  cytoplasm; membrane; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IB; plasma membrane
Molecular Function:  1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; ephrin receptor binding; identical protein binding; kinase activity; nucleotide binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  angiogenesis; cell migration; cellular response to cAMP; chemotaxis; endocytosis; G protein-coupled receptor signaling pathway; hepatocyte apoptotic process; immune system process; inflammatory response; negative regulation of fibroblast apoptotic process; negative regulation of triglyceride catabolic process; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of acute inflammatory response; positive regulation of catalytic activity; positive regulation of cytosolic calcium ion concentration; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; protein phosphorylation; regulation of calcium ion transmembrane transport; regulation of protein phosphorylation; secretory granule localization
Reference #:  Q9JHG7 (UniProtKB)
Alt. Names/Synonyms: 5830428L06Rik; p110gamma; p120-PI3K; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3-kinase subunit gamma; PI3K-gamma; Pi3kg1; PI3Kgamma; Pik3cg; PK3CG; PtdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma
Gene Symbols: Pik3cg
Molecular weight: 126,400 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PIK3CG

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene