|
TSC2 iso3
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor |
| Chromosomal Location of human Ortholog: 16p13.3 |
|
Cellular Component:
cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; TSC1-TSC2 complex
|
|
Molecular Function:
GTPase activator activity; Hsp90 protein binding; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding
|
|
Biological Process:
anoikis; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell population proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of mitophagy; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling; negative regulation of TOR signaling; negative regulation of Wnt signaling pathway; neural tube closure; positive chemotaxis; positive regulation of GTPase activity; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of small GTPase mediated signal transduction; vesicle-mediated transport
|
|
Disease: Lymphangioleiomyomatosis; Tuberous Sclerosis 1
|
|
Reference #:
P49815-3
(UniProtKB)
|
|
Alt. Names/Synonyms: FLJ43106; LAM; PPP1R160; protein phosphatase 1, regulatory subunit 160; TSC complex subunit 2; TSC2; TSC2 iso3; TSC4; Tuberin; tuberous sclerosis 2; Tuberous sclerosis 2 protein
|
|
Gene Symbols: TSC2
|
|
Molecular weight:
195,760 Da
|
|
Basal Isoelectric point:
6.7
Predict pI for various phosphorylation states
|
|
CST Pathways:
AMPK Signaling
|
Growth And Differentiation Control by MAPKs
|
Insulin Receptor Signaling
|
mTOR Signaling
|
PI3K/Akt Signaling
|
Translation: eIF4E and p70S6K
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
