PIK3CB catalytic subunit of phosphoinositide-3-kinase beta. Catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Expressed ubiquitously. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q22.3
Cellular Component:  cytosol; midbody; nucleolus; nucleus
Molecular Function:  ATP binding; insulin receptor substrate binding; kinase activity; phosphatidylinositol 3-kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding
Biological Process:  activation of MAPK activity; angiogenesis involved in wound healing; autophagy; axon guidance; cell migration; cellular calcium ion homeostasis; chemotaxis; cytokine-mediated signaling pathway; embryonic cleavage; endocytosis; endothelial cell proliferation; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; G protein-coupled receptor signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; leukocyte migration; phosphatidylinositol 3-kinase signaling; phosphatidylinositol biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; platelet activation; platelet aggregation; positive regulation of autophagy; positive regulation of gene expression; positive regulation of neutrophil apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; regulation of cell-matrix adhesion; regulation of clathrin-dependent endocytosis; signal transduction; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  P42338 (UniProtKB)
Alt. Names/Synonyms: catalytic phosphatidylinositol 3-kinase beta; DKFZp779K1237; MGC133043; P110BETA; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K-beta; PI3KBETA; PIK3C1; PIK3CB; PK3CB; PtdIns-3-kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta
Gene Symbols: PIK3CB
Molecular weight: 122,762 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PIK3CB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene