WIPF1 a cytoskeleton-associated protein that interacts with the Wiskott-Aldrich syndrome protein (WASP) in resting cells. Plays an important role in the organization of the actin cytoskeleton. Phosphorylation by PKC-theta following T cell receptor signaling disengages it from WASP, releasing WASP from WIP inhibition. Binds to a region of WASP that is frequently mutated in Wiskott-Aldrich syndrome. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q23
Cellular Component:  actin cortical patch; actin cytoskeleton; actin filament; cytoplasmic vesicle; ruffle
Molecular Function:  actin binding; actin filament binding; protein binding; SH3 domain binding
Biological Process:  actin cortical patch assembly; actin cortical patch localization; actin cytoskeleton organization; actin filament-based movement; actin polymerization or depolymerization; endocytosis; positive regulation of protein export from nucleus; response to other organism
Reference #:  Q6IN36 (UniProtKB)
Alt. Names/Synonyms: WAS/WASL interacting protein family, member 1; WAS/WASL-interacting protein family member 1; WASP interacting protein; WASP-interacting protein; Waspip; Wip; Wipf1; Wiskott-Aldrich syndrome protein interacting protein; Wiskott-Aldrich syndrome protein-interacting protein
Gene Symbols: Wipf1
Molecular weight: 49,751 Da
Basal Isoelectric point: 11.42  Predict pI for various phosphorylation states
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WIPF1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene