WIPF1 Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles. Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. Belongs to the verprolin family. Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2 C3|2 43.68 cM
Cellular Component:  actin cortical patch; actin cytoskeleton; actin filament; cell projection; cytoplasm; cytoplasmic vesicle; cytoskeleton
Molecular Function:  actin binding; actin filament binding; protein binding; SH3 domain binding
Biological Process:  actin cortical patch assembly; actin cortical patch localization; actin cytoskeleton organization; actin filament-based movement; actin polymerization or depolymerization; endocytosis; positive regulation of protein export from nucleus; response to other organism
Reference #:  Q8K1I7 (UniProtKB)
Alt. Names/Synonyms: AI115543; D2Ertd120e; OTTMUSP00000014408; OTTMUSP00000014409; OTTMUSP00000014410; WAS/WASL interacting protein family, member 1; WAS/WASL-interacting protein family member 1; WASP interacting protein; WASP-interacting protein; Waspip; Wip; Wipf1; Wiskott-Aldrich syndrome protein interacting protein; Wiskott-Aldrich syndrome protein-interacting protein
Gene Symbols: Wipf1
Molecular weight: 50,080 Da
Basal Isoelectric point: 11.42  Predict pI for various phosphorylation states
Select Structure to View Below

WIPF1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene