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WIPF1
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles. Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. Belongs to the verprolin family. Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 2q31.1 |
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Cellular Component:
actin cytoskeleton; actin filament; cytoplasmic vesicle; cytosol; ruffle
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Molecular Function:
actin binding; profilin binding; protein binding; protein folding chaperone; SH3 domain binding
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Biological Process:
actin filament-based movement; actin polymerization or depolymerization; protein folding; protein-containing complex assembly; response to other organism
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Disease: Wiskott-aldrich Syndrome 2
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Reference #:
O43516
(UniProtKB)
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Alt. Names/Synonyms: MGC111041; Protein PRPL-2; PRPL-2; testicular tissue protein Li 226; WAS/WASL interacting protein family member 1; WAS/WASL interacting protein family, member 1; WAS/WASL-interacting protein family member 1; WAS2; WASP-interacting protein; WASPIP; WIP; WIPF1; Wiskott-Aldrich syndrome protein interacting protein; Wiskott-Aldrich syndrome protein-interacting protein
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Gene Symbols: WIPF1
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Molecular weight:
51,258 Da
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Basal Isoelectric point:
11.47
Predict pI for various phosphorylation states
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