KCTD21 Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 11q14.1
Cellular Component: 
Molecular Function:  cullin family protein binding; histone deacetylase binding; identical protein binding
Biological Process:  negative regulation of smoothened signaling pathway; protein homooligomerization; protein ubiquitination; regulation of growth; ubiquitin-dependent protein catabolic process
Reference #:  Q4G0X4 (UniProtKB)
Alt. Names/Synonyms: BTB/POZ domain-containing protein KCTD21; KCASH2; KCASH2 protein; KCD21; KCTD21; potassium channel tetramerisation domain containing 21; potassium channel tetramerization domain containing 21; Potassium channel tetramerization domain-containing protein 21
Gene Symbols: KCTD21
Molecular weight: 29,643 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene